Company Filing History:
Years Active: 2011-2014
Title: Innovations by Madaiah Puttaraju in RNA Trans-Splicing
Introduction
Madaiah Puttaraju, based in Germantown, MD, is a distinguished inventor known for his impactful contributions to the field of molecular biology and gene therapy. With a total of four patents to his name, his inventions focus on pioneering methods and compositions that improve the understanding and treatment of genetic disorders.
Latest Patents
Among Madaiah Puttaraju's latest innovations are sophisticated methods and compositions aimed at generating novel nucleic acid molecules through targeted spliceosome-mediated RNA trans-splicing. One of his notable patents outlines a process resulting in the expression of the apoAI protein, specifically a variant known as the apoAI Milano variant. This invention includes pre-trans-splicing molecules (PTMs) designed to engage with target precursor messenger RNA (pre-mRNA) molecules, leading to the formation of chimeric RNA capable of encoding apoAI. The protective benefits of this innovation are crucial in addressing vascular disorders such as atherosclerosis, strokes, and heart attacks.
Another key patent focuses on correcting alpha-1-antitrypsin genetic defects using spliceosome-mediated RNA trans-splicing. This invention provides methods and compositions for generating chimeric RNA molecules aimed at addressing AAT deficiency, a condition resulting from SERPINA1 genetic defects. The PTMs included in this patent not only assist in correcting these defects but may also produce duplex siRNA molecules that specifically target mutant SERPIN A1 mRNAs, offering a novel approach to reducing the toxic accumulation of AAT protein in liver cells.
Career Highlights
Currently, Madaiah Puttaraju is associated with Virxsys Corporation, where his innovative work continues to push the boundaries of genetic research and therapeutics. His dedication to developing cutting-edge techniques has set the stage for advancements in the treatment of various genetic disorders, making him a prominent figure in his field.
Collaborations
During his career, Madaiah Puttaraju has collaborated with esteemed colleagues, including Mariano A. Garcia-Blanco and Gerard J. McGarrity. These partnerships have fostered a rich environment for innovation and have enhanced the development of transformative therapies aimed at addressing critical health issues.
Conclusion
Madaiah Puttaraju's inventive contributions in the realm of RNA trans-splicing illustrate the power of innovative thinking in addressing complex genetic disorders. With a commitment to advancing scientific knowledge and therapeutic applications, he remains a pivotal player in biotechnology. His work not only holds the promise of improved treatment options but also paves the way for future breakthroughs in the field of molecular genetics.