Company Filing History:
Years Active: 2015-2023
Title: Lynne Apone: Innovator in DNA Fragmentation Technologies
Introduction
Lynne Apone is a prominent inventor based in Waltham, MA (US). She has made significant contributions to the field of molecular biology, particularly in the area of DNA manipulation. With a total of 2 patents to her name, her work has advanced the understanding and application of DNA fragmentation techniques.
Latest Patents
Lynne Apone's latest patents include innovative methods and compositions for fragmenting double-stranded DNA. One of her notable inventions is a polymerase-free enzyme mix (FRAG) designed for this purpose. This enzyme mix may include a double-stranded DNA nickase and a DNA ligase capable of sealing nicks within DNA, as well as a single-strand specific DNA nuclease. Additionally, she has developed compositions and methods related to a novel family of enzymes that preferentially bind to hydroxymethylated cytosine or glucosylated hydroxymethylated cytosine. These enzymes cleave double-stranded DNA at a defined distance 3' of the recognition site, producing cleavage fragments with a 1-3 base overhang.
Career Highlights
Lynne Apone is currently associated with New England Biolabs, Inc., where she continues to innovate in the field of biotechnology. Her work has been instrumental in developing tools that enhance DNA research and applications.
Collaborations
Throughout her career, Lynne has collaborated with esteemed colleagues, including Zhenyu Zhu and Yu Brian Zheng. These partnerships have fostered a collaborative environment that promotes scientific advancement.
Conclusion
Lynne Apone's contributions to DNA fragmentation technologies exemplify her dedication to innovation in molecular biology. Her patents and ongoing work at New England Biolabs, Inc. continue to influence the field significantly.