The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2015

Filed:

Jan. 20, 2011
Applicants:

Zhenyu Zhu, Beverly, MA (US);

Yu Zheng, Topsfield, MA (US);

Shengxi Guan, Stoneham, MA (US);

Hua Wang, Topsfield, MA (US);

Aine Quimby, Newton, NH (US);

Penghua Zhang, Lexington, MA (US);

Lynne Apone, Waltham, MA (US);

Inventors:

Zhenyu Zhu, Beverly, MA (US);

Yu Zheng, Topsfield, MA (US);

Shengxi Guan, Stoneham, MA (US);

Hua Wang, Topsfield, MA (US);

Aine Quimby, Newton, NH (US);

Penghua Zhang, Lexington, MA (US);

Lynne Apone, Waltham, MA (US);

Assignee:

New England Biolabs, Inc., Ipswich, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/00 (2006.01); C12Q 1/68 (2006.01); C12Q 1/34 (2006.01); C12N 9/00 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C12Q 1/6827 (2013.01);
Abstract

Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3' of the recognition site to produce a cleavage fragment with a 1-3 base overhang.


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