Company Filing History:
3 out of 8 
1 out of 1,264 Years Active: 2012-2023
Title: Lu Yang: Innovator in Fusion Protein Technology
Introduction
Lu Yang is a prominent inventor based in Shanghai, China. He has made significant contributions to the field of biotechnology, particularly in the development of fusion proteins. With a total of 4 patents, his work has the potential to impact various medical applications.
Latest Patents
One of Lu Yang's latest patents is a linker peptide for constructing fusion proteins. This innovative linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units, while the rigid peptide consists of one or more rigid units. The flexible unit includes two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit features a human chorionic gonadotropin β-subunit carboxy-terminal peptide (CTP) that bears multiple glycosylation sites. This linker peptide effectively eliminates mutual steric hindrance of two fusion molecules, reducing the loss of polymerization or activity due to improper folding or conformational changes. Additionally, the negatively charged, highly sialylated CTP can resist renal clearance, prolonging the half-life of the fused molecule and enhancing its bioavailability. Furthermore, the protective effect of the glycosylated side chain CTP lowers the protease sensitivity of the linker peptide, making the linker region of the fusion protein less degradable.
Another significant patent is related to an anti-PD-1 antibody that specifically binds to PD-1 with high affinity. This patent includes a nucleic acid molecule for coding the antibody, an expression vector, and a host cell for expressing the antibody. It also outlines a production method for the antibody, along with an immunoconjugate and a pharmaceutical composition that includes the antibody. The use of this antibody is aimed at preparing drugs for treating cancers, infectious diseases, and inflammatory diseases.
Career Highlights
Lu Yang has worked with notable companies such as Ampsource Biopharma Shanghai Inc. and Integrated Device Technology, Inc. His experience in these organizations has contributed to his expertise in the field of biotechnology and innovation.
Collaborations
Lu Yang has collaborated with several professionals, including Qiang Li and Yuanli Li, who have contributed to his research and development efforts.
Conclusion
Lu Yang's innovative work in the field of fusion proteins and antibody development showcases his significant contributions to biotechnology