New City, NY, United States of America

Louis Kaplan


Average Co-Inventor Count = 4.4

ph-index = 6

Forward Citations = 104(Granted Patents)


Location History:

  • New York City, NY (US) (1993)
  • New City, NY (US) (1983 - 1995)

Company Filing History:


Years Active: 1983-1995

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13 patents (USPTO):Explore Patents

Title: Innovations by Louis Kaplan: A Pioneer in Immunosuppressant and Antibiotic Development

Introduction

Louis Kaplan is a distinguished inventor based in New City, NY, known for his significant contributions in the field of biomedical research. With an impressive portfolio of 13 patents to his name, he has played a crucial role in advancing medical innovations that enhance patient care, particularly in organ transplantation and antibiotic development.

Latest Patents

One of Kaplan's latest patents is the development of a microbial immunoregulant, specifically L-687,819. This compound is a C-31 demethylated derivative of L-683,795 (FK-523) and is produced through fermentation using a new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646). This macrolide immunosuppressant has immense potential in preventing human host rejection during organ transplants, such as bone marrow and heart transplants.

Additionally, he has patented a process for producing an antibiotic compound from Zalerion arboricola. This process transforms what is normally a minor component in the cultivation of Z. arboricola into a major antibiotic product, highlighting his innovative approach to antibiotic production.

Career Highlights

Louis Kaplan works at Merck & Company, Inc., a leading global healthcare company committed to improving health outcomes for patients worldwide. Over the years, his work has significantly influenced the development of new therapeutic agents that are vital for patient care.

Collaborations

Throughout his career, Kaplan has collaborated with talented coworkers, including Prakash S. Masurekar and Kevin M. Byrne. These collaborations have fostered an environment of innovation, leading to the successful development of novel medical compounds that address critical health issues.

Conclusion

Louis Kaplan's work exemplifies the power of innovation and collaboration in the field of biomedical research. His patents not only pave the way for groundbreaking advancements in immunosuppression and antibiotic production but also enhance the lives of countless patients receiving vital organ transplants. As a respected inventor, Kaplan continues to inspire future generations of innovators in the realm of medical science.

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