Company Filing History:
Years Active: 1999-2001
Title: The Innovations of Loren J Miraglia
Introduction
Loren J Miraglia is a notable inventor based in Encinitas, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of antisense oligonucleotide therapies. With a total of 5 patents to his name, Miraglia's work has the potential to impact the treatment of various diseases.
Latest Patents
Among his latest patents is a groundbreaking invention related to antisense oligonucleotide compositions and methods for the modulation of activating protein 1. This patent provides compositions and methods for the treatment and diagnosis of diseases that can be addressed through modulation of Activating Protein 1 (AP-1) expression. The invention includes oligonucleotides that are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, the method focuses on modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits. This can be achieved using the oligonucleotides of the invention or any other agent that modulates AP-1 or AP-1-mediated transcription. Another significant patent involves antisense oligonucleotide modulation of human mdm2 expression. This invention provides compounds, compositions, and methods for inhibiting the expression of human mdm2, which is crucial for treating cancers associated with its overexpression.
Career Highlights
Loren J Miraglia has been associated with Isis Pharmaceuticals, Inc., where he has contributed to various innovative projects. His work has been instrumental in advancing the understanding and application of antisense technology in therapeutic settings.
Collaborations
Miraglia has collaborated with notable colleagues such as Nicholas M Dean and Robert McKay, further enhancing the impact of his research and inventions.
Conclusion
Loren J Miraglia's contributions to biotechnology through his patents and collaborations highlight his role as an influential inventor in the field. His work continues to pave the way for innovative treatments that could change the landscape of disease management.