The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2001
Filed:
Mar. 26, 1999
Applicant:
Inventors:
Loren J. Miraglia, Encinitas, CA (US);
Pamela Nero, Oceanside, CA (US);
Mark J. Graham, San Clemente, CA (US);
Brett P. Monia, La Costa, CA (US);
Lex M. Cowsert, Carlsbad, CA (US);
Assignee:
Isis Pharmaceuticals Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 2/104 ; A61K 4/800 ; C12Q 1/68 ; C12N 1/585 ; C12N 1/586 ;
U.S. Cl.
CPC ...
C07H 2/104 ; A61K 4/800 ; C12Q 1/68 ; C12N 1/585 ; C12N 1/586 ;
Abstract
Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.