Liyanage Parakrama Perera

Title: Innovations by Liyanage Parakrama Perera: Pioneering Chimeric Antigen Receptors

Introduction

Liyanage Parakrama Perera is an accomplished inventor based in Bethesda, MD, USA. He holds three patents, showcasing his contributions to the field of biomedical innovation. His most notable work involves the development of chimeric antigen receptors that target the chemokine receptor CCR4, which holds promise in the treatment of various malignancies.

Latest Patents

One of Liyanage Perera's latest patents describes a chimeric antigen receptor (CAR) that includes several crucial components. The design features a single-chain variable fragment (scFv) comprising a light chain variable domain (V) and a heavy chain variable domain (V) that specifically binds to CCR4. The CAR also encompasses a hinge and transmembrane domain derived from CD8, alongside intracellular signaling domains including 4-1BB and CD3 zeta. This configuration, organized in N to C terminal order, aims to enhance the therapeutic efficacy of T-cell therapies for malignancies.

Career Highlights

Liyanage has had a distinguished career working with leading governmental organizations, including the Government of the United States of America as represented by the Secretary of the Department of Health and Human Services, and the United States Government as represented by the Department of Veterans Affairs. His role in these organizations has greatly contributed to advancements in health technology and innovation.

Collaborations

Throughout his career, Liyanage has collaborated with esteemed colleagues such as Thomas Alexander Waldmann and Kevin Charles Conlon. These partnerships have fostered an environment of shared expertise and innovation, leading to significant advancements in biomedical research.

Conclusion

Liyanage Parakrama Perera's work stands at the forefront of innovation in chimeric antigen receptors, offering new solutions for treating malignancies. His extensive patent portfolio and collaborations highlight his role as a leading inventor in the field, paving the way for future advancements in health technology and therapeutic interventions.