The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2024
Filed:
Jun. 21, 2021
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
The United States Government As Represented BY the Department of Veterans Affairs, Washington, DC (US);
Liyanage Parakrama Perera, Bethesda, MD (US);
Thomas Alexander Waldmann, Bethesda, MD (US);
Kevin Charles Conlon, Bethesda, MD (US);
Pin-Yu Perera, Washington, DC (US);
Abstract
A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (V) and a heavy chain variable domain (V), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.