Liu Sun

Title: Liu Sun: Innovator in Heparin Skeleton Synthase Technology

Introduction

Liu Sun is a prominent inventor based in Jinan, China. He is known for his significant contributions to the field of biochemistry, particularly in the development of heparin skeleton synthase and its mutants. His innovative work has led to advancements in enzyme expression levels, which have important implications for biotechnology.

Latest Patents

Liu Sun holds a patent for "Heparin skeleton synthase and its mutants and application." This patent describes a heparin skeleton synthase that originates from a specific amino acid sequence, as shown in SEQ ID NO.2, and a nucleotide sequence of the coding gene, as shown in SEQ ID NO.1. The recombinant expression level of this synthase is 6.8 times that of the existing heparin skeleton synthase KfiA from K5. Additionally, the total enzyme activity per fermentation liquor is 5.22 times that of KfiA. The mutants obtained through site-directed mutagenesis at various sites in the amino acid sequence exhibit high expression levels, showcasing the potential for enhanced enzyme production.

Career Highlights

Liu Sun has made significant strides in his career, working with esteemed institutions such as Shandong University and Bloomage Biotechnology Corporation Limited. His research has focused on improving the efficiency and effectiveness of heparin synthesis, which is crucial for various medical applications.

Collaborations

Liu has collaborated with notable colleagues, including Juzheng Sheng and Xueping Guo, who have contributed to his research endeavors. Their combined expertise has furthered the understanding and application of heparin skeleton synthase technology.

Conclusion

Liu Sun's innovative work in the field of heparin skeleton synthase represents a significant advancement in biotechnology. His contributions have the potential to impact various medical applications, making him a noteworthy inventor in this domain.