Lisa M Johnson

Title: Innovations of Lisa M Johnson

Introduction

Lisa M Johnson is a prominent inventor based in Marshall, MN (US). She has made significant contributions to the field of biotechnology, particularly in the development of peptide analogs and biologically active polypeptides. With a total of 6 patents to her name, her work has the potential to impact the treatment of diabetes and other health conditions.

Latest Patents

One of her latest patents is titled "Alpha/beta-polypeptide analogs of glucagon-like peptide 1." This patent describes peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity while being more resistant to proteolytic degradation than native GLP-1. In these analogs, at least one α-amino acid found in the native GLP-1 is replaced with a β-amino acid residue, which may or may not be cyclically constrained. The patent also covers pharmaceutical compositions containing these analogs, methods to treat diabetes, and methods to create proteolytically resistant GLP-1 analogs.

Another significant patent is "Method of making biologically active alpha-beta peptides." This patent outlines a method for fabricating biologically active, unnatural polypeptides. The process includes selecting a biologically active polypeptide or fragment with an amino acid sequence comprising α-amino acid residues and fabricating a synthetic polypeptide that corresponds to the sequence of the biologically active polypeptide. In this method, about 14% to 50% of the α-amino acid residues are replaced with β-amino acid residues, distributed in a repeating pattern.

Career Highlights

Throughout her career, Lisa has worked with notable organizations, including the Wisconsin Alumni Research Foundation and Harvard College. Her innovative work has garnered attention in the scientific community and has contributed to advancements in peptide research.

Collaborations

Lisa has collaborated with esteemed colleagues such as Samuel Helmer Gellman and William Seth Horne. Their combined expertise has furthered the development of her groundbreaking inventions.

Conclusion

Lisa M Johnson's contributions to the field of biotechnology through her innovative patents and collaborations highlight her role as a leading inventor. Her work continues to pave the way for advancements in medical treatments and research.