Wisconsin Alumni Research Foundation

Harvard College

Accenture Global Services Gmbh

Lisa M Johnson

Samuel Helmer Gellman

William Seth Horne

Alan D Attie

Alan Saghatelian

Mark Patrick Keller

Jay Michael Reseigh

Michael Joseph Arnold, Jr

Kimberly F DeShong

Michael Joseph Arnold

Kimberly F Deshong

Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least one &#x3b1;-amino acid found in the native GLP-1 is replaced with a &#x3b2;-amino acid residue, which may or may not be cyclically constrained. Pharmaceutical compositions containing the analogs are described, as are methods to treat diabetes, and methods to make proteolytically resistant GLP-1 analogs.

Alpha/beta-polypeptide analogs of glucagon-like peptide 1

Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising &#x3b1;-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide, but wherein about 14% to about 50% of the &#x3b1;-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with &#x3b2;-amino acid residues, and the &#x3b1;-amino acid residues are distributed in a repeating pattern.

Method of making biologically active alpha-beta peptides

Alpha/beta-polypeptide analogs of glucagon-like peptide-1

An improved security checkpoint separates certain individuals into a secure, enclosed wanding station for additional security screening. The wanding station may be constructed using glass (or other strong, visually transparent substance) and metallic (such as aluminum or steel) posts so that people may be securely enclosed in the wanding station but still have a direct line of sight to personal items being screened at another location. The size of the wanding station may vary according to the needs of the checkpoint but preferably has room to screen three people simultaneously. The wanding station may include an entry area in which people form a queue, optimally of six people, for entering the wanding station. Two or more personal and item screening areas may share a wanding station to form a double lane module. The security module is configured so that most people pass straight through the checkpoint, and people leaving the wanding station can easily obtain their items without delaying others. The security module may further include a small item x-ray or other screening device positioned near the wanding station to expedite the screening within the wanding station.

Security checkpoint

Growing community of inventors

Marshall, MN, United States of America

Lisa M Johnson