Lior Mayo

Title: Lior Mayo: Innovator in Neurodegenerative Disease Treatment

Introduction

Lior Mayo is a prominent inventor based in Fivataim, IL. He has made significant contributions to the field of neurodegenerative diseases, particularly through his innovative research and patent.

Latest Patents

Lior Mayo holds a patent focused on treating neurodegenerative diseases. His patent addresses the up-regulation of lactosylceramide (LacCer) levels in the central nervous system (CNS) during chronic experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS). The research indicates that LacCer acts in an autocrine manner, triggering transcriptional programs that promote the recruitment and activation of CNS infiltrating monocytes and microglia, leading to neurodegeneration. Furthermore, increased expression of B4GALT6 and LacCer levels were observed in CNS MS lesions in human patients. The inhibition of LacCer synthesis was found to suppress local CNS innate immunity and neurodegeneration in EAE, as well as interfere with the activation of human astrocytes in vitro. This research positions B4GALT6 as a therapeutic target for MS and other neuroinflammatory disorders. Lior Mayo has 1 patent to his name.

Career Highlights

Lior Mayo is affiliated with The Brigham and Women's Hospital, Inc., where he continues to advance his research in neurodegenerative diseases. His work has garnered attention for its potential impact on treatment strategies for conditions like multiple sclerosis.

Collaborations

Lior has collaborated with notable colleagues, including Francisco Javier Quintana and Howard L Weiner, contributing to a rich environment of innovation and research.

Conclusion

Lior Mayo's work in the field of neurodegenerative diseases exemplifies the importance of innovative research in developing therapeutic strategies. His contributions are paving the way for advancements in treating complex neurological conditions.