Company Filing History:
Years Active: 2006-2023
Title: Linhong Li: Innovator in Genomic DNA Modification
Introduction
Linhong Li is a prominent inventor based in North Potomac, MD (US), known for his significant contributions to the field of genomic DNA modification. With a total of 11 patents to his name, he has made remarkable strides in developing methods that enhance genetic engineering and therapeutic applications.
Latest Patents
Linhong Li's latest patents include innovative methods for modifying genomic DNA. One of his notable inventions focuses on compositions and methods concerning the sequence modification of an endogenous genomic DNA region. This method involves site-specific sequence modification of a target genomic DNA region in cells by contacting the cells with an activating composition and transfecting them with a transfection composition that includes donor DNA and a DNA digesting agent. The donor DNA comprises a homologous region and a sequence modification region, allowing for precise modifications at the target genomic DNA region.
Another significant patent relates to the engineering and delivery of therapeutic compositions of freshly isolated cells. This invention addresses the transient modification of immune system cells, such as PBMC, PBL, T (CD3+ and/or CD8+), and Natural Killer (NK) cells. The modified cells express a genetically engineered chimeric receptor, which can be therapeutically administered to patients. The methods described in this patent efficiently deliver mRNA coding for the chimeric receptor to unstimulated resting immune cells, promoting significant target cell killing.
Career Highlights
Linhong Li has established himself as a key figure in the field of genetic engineering through his work at Maxcyte Inc. His innovative approaches have not only advanced scientific understanding but also paved the way for new therapeutic strategies in medicine.
Collaborations
Linhong Li collaborates with esteemed colleagues, including Madhusudan V Peshwa and Sergey Dzekunov, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Linhong Li's work in genomic DNA modification exemplifies the intersection of science and technology, showcasing the potential for transformative advancements in therapeutic applications. His contributions continue to influence the field and inspire future innovations.