Li-Tzu Chen

Title: Innovations of Li-Tzu Chen in Glycoprotein Remodeling

Introduction

Li-Tzu Chen is a notable inventor based in Taipei, Taiwan. He has made significant contributions to the field of glycoprotein remodeling, with a focus on endoglycosidase mutants. His innovative work has led to the development of methods that enhance the efficiency of glycoprotein engineering.

Latest Patents

Li-Tzu Chen holds 2 patents related to his research. His latest patents include "Methods for glycoprotein remodeling using endoglycosidase mutants" and "Endoglycosidase mutants for glycoprotein remodeling and methods of using it." Both patents describe a mutant of EndoS2 that possesses one or more mutations in specific peptide regions. These mutants exhibit low hydrolyzing activity and high transglycosylation activity compared to the wild-type EndoS2. The methods outlined involve coupling an activated oligosaccharide, specifically a glycan oxazoline, to a glycoprotein acceptor.

Career Highlights

Throughout his career, Li-Tzu Chen has worked with esteemed organizations such as Academia Sinica and Cho Pharma Inc. His research has been pivotal in advancing the understanding and application of glycoprotein engineering.

Collaborations

Li-Tzu Chen has collaborated with notable colleagues, including Nan-Horng Lin and Lin-Ya Huang, who have contributed to his research endeavors.

Conclusion

Li-Tzu Chen's innovative work in glycoprotein remodeling showcases his expertise and dedication to advancing biotechnological applications. His patents reflect a significant step forward in the field, promising to enhance the efficiency of glycoprotein engineering.