Li Guo

Title: The Innovative Contributions of Li Guo

Introduction

Li Guo is a prominent inventor based in Blue Bell, PA (US). She has made significant contributions to the field of chemistry, particularly in the development of novel compounds and methods. With a total of 6 patents to her name, her work has garnered attention for its potential applications in various scientific domains.

Latest Patents

One of Li Guo's latest patents focuses on gamma amino acid building blocks. This invention provides compounds and methods for conducting organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds, catalyzed by a proline derivative. The result is the formation of cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can achieve enantioselectivity when a chiral pyrrolidine catalyst is employed, yielding Michael adducts in nearly optically pure form, ranging from 96% to >99% enantiomeric excess. These Michael adducts can possess either a single substituent or dual substituents adjacent to the carbonyl. Furthermore, they can be efficiently converted into cyclically constrained protected γ-amino acid residues, which are crucial for systematic conformational studies of γ-peptide foldamers. New methods are also introduced for preparing other γ-amino acids and peptides. These innovative building blocks can be utilized to create foldamers, such as α/γ-peptide foldamers, that adopt specific helical conformations in both solution and solid states.

Career Highlights

Li Guo is associated with the Wisconsin Alumni Research Foundation, where she continues to advance her research and innovation. Her work has not only contributed to her personal achievements but has also enhanced the foundation's reputation in the scientific community.

Collaborations

Li Guo has collaborated with notable colleagues, including Samuel Helmer Gellman and Michael Giuliano. These partnerships have fostered a collaborative environment that encourages the exchange of ideas and the advancement of research.

Conclusion

Li Guo's innovative work in the field of chemistry, particularly her contributions to the development of gamma amino acid building blocks, showcases her dedication to advancing scientific knowledge. Her patents reflect her commitment to innovation and her impact on the scientific community.