The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2010
Filed:
Mar. 26, 2007
Yonggui Chi, Berkeley, CA (US);
Samuel H. Gellman, Madison, WI (US);
William C. Pomerantz, Madison, WI (US);
William S. Horne, Madison, WI (US);
LI Guo, Madison, WI (US);
Emily P. English, Madison, WI (US);
Yonggui Chi, Berkeley, CA (US);
Samuel H. Gellman, Madison, WI (US);
William C. Pomerantz, Madison, WI (US);
William S. Horne, Madison, WI (US);
Li Guo, Madison, WI (US);
Emily P. English, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
The present invention provides a method for the synthesis of β-amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β-amino acids.