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Title: The Innovative Contributions of Li-Chen Chou
Introduction
Li-Chen Chou is a prominent inventor based in Taichung, Taiwan. He has made significant contributions to the field of pharmaceuticals, particularly in the development of anticancer agents. With a total of 10 patents to his name, Chou's work has garnered attention for its potential impact on cancer treatment.
Latest Patents
Among his latest patents are the compounds 2-aryl-4-quinazolinones and their pharmaceutical compositions. This patent provides a compound of the formula I or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof. Another notable patent involves 2-phenyl-4-quinolones as anticancer agents. In this process, 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates. These phosphates are then subjected to hydrogenation to replace dibenzyl groups with hydrogen, followed by a reaction with Amberlite IR-120 (Naform) to form disodium salts. Preliminary screening results have revealed that these phosphates exhibit significant anti-cancer activity. Additionally, Chou has synthesized novel intermediates, including 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones, which also demonstrate significant anticancer activities.
Career Highlights
Li-Chen Chou has worked with notable institutions such as China Medical University and Yung Shin Pharmaceutical Industry Co., Ltd. His research and innovations have played a crucial role in advancing pharmaceutical science, particularly in the area of cancer treatment.
Collaborations
Chou has collaborated with esteemed colleagues, including Sheng-Chu Kuo and Jai-Sing Yang, to further his research and development efforts. These collaborations have enhanced the scope and impact of his work in the pharmaceutical field.
Conclusion
Li-Chen Chou's innovative contributions to the development of anticancer agents highlight his significant role in pharmaceutical research. His patents and collaborations reflect a commitment to advancing medical science and improving treatment options for cancer patients.