The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
May. 13, 2013
China Medical University, Taichung, TW;
Sheng-Chu Kuo, Taichung, TW;
Che-Ming Teng, Taipei, TW;
Kuo-Hsiung Lee, Chapel Hill, NC (US);
Li-Jiau Huang, Taichung, TW;
Li-Chen Chou, Taichung, TW;
Chih-Shiang Chang, Taichung, TW;
Chung-Ming Sun, Hsinchu, TW;
Tian-Shung Wu, Tainan, TW;
Shiow-Lin Pan, Taipei, TW;
Tzong-Der Way, Taichung, TW;
Jang-Chang Lee, Taichung, TW;
Jing-Gung Chung, Taichung, TW;
Jai-Sing Yang, Taichung, TW;
Chien-Ting Chen, Taichung, TW;
Ching-Che Huang, Taichung, TW;
Shih-Ming Huang, Taichung, TW;
China Medical University, Taichung, TW;
Abstract
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Naform) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.