Company Filing History:
Years Active: 2013-2021
Title: Innovations of Chih-Shiang Chang in Cancer Research
Introduction
Chih-Shiang Chang is a prominent inventor based in Taichung, Taiwan. He has made significant contributions to the field of cancer research through his innovative inventions. With a total of six patents to his name, Chang's work focuses on developing novel therapeutic agents aimed at combating cancer.
Latest Patents
One of Chang's latest patents is titled "Irreversible inhibitors of pyruvate kinase M2 and the use thereof." This invention introduces a new class of propiolylamide-based irreversible inhibitors of PKM2. The compounds are designed to induce an anti-tumor effect in subjects suffering from tumors by administering a pharmaceutical composition containing an effective amount of these compounds.
Another notable patent is "2-phenyl-4-quinolones as anticancer agents." In this invention, 2-aryl-4-quinolones are converted into phosphates through a reaction with tetrabenzyl pyrophosphate. The resulting dibenzyl phosphates undergo hydrogenation to replace dibenzyl groups with hydrogen, followed by a reaction with Amberlite IR-120(Naform) to form disodium salts. Preliminary screening results indicate that these phosphates exhibit significant anti-cancer activity. Additionally, novel intermediates such as 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones have also been synthesized, showcasing significant anticancer activities.
Career Highlights
Chih-Shiang Chang is affiliated with China Medical University, where he continues to advance his research in cancer therapeutics. His innovative approaches and dedication to scientific inquiry have positioned him as a key figure in the field.
Collaborations
Chang has collaborated with notable colleagues, including Sheng-Chu Kuo and Che-Ming Teng. Their combined expertise enhances the potential impact of their research on cancer treatment.
Conclusion
Chih-Shiang Chang's contributions to cancer research through his innovative patents demonstrate his commitment to finding effective treatments for this challenging disease. His work continues to inspire advancements in the field of oncology.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.