Company Filing History:
Years Active: 2016-2021
Title: The Innovative Contributions of Leslie A McSweeney
Introduction
Leslie A McSweeney is a prominent inventor based in Milford, MA (US). She has made significant contributions to the field of biotechnology, particularly in the development of novel fusion proteins. With a total of 3 patents to her name, her work has the potential to impact various therapeutic applications.
Latest Patents
One of her latest patents focuses on single chain Fc fusion proteins. This invention provides novel, single chain Fc fusion proteins that exhibit improved properties. The invention includes single chain fusions of soluble proteins fused to the Fc region of an immunoglobulin via a unique linker. This linker comprises a constant region of an immunoglobulin light chain linked to a CH1 constant region of an immunoglobulin heavy chain. The novel linker enhances the bioactivity and increases the half-life of the Fc fusion proteins compared to non-Fc fusion counterparts or prior art Fc fusion proteins. Additionally, the Fc fusion protein scaffold can be designed to include soluble proteins capable of binding or interacting with various targets. Preferably, the Fc fusion protein is a dimer that forms through a disulfide bond between free cysteine residues in the hinge region of two monomeric Fc fusion proteins.
Another significant patent involves fusion polypeptides comprising mucin-domain polypeptide linkers. This invention provides fusion proteins that demonstrate improved bioactivity. The first polypeptide fusion partner is linked to the second polypeptide fusion partner by a mucin-domain polypeptide linker. The bioactivity of the fusion protein is enhanced compared to the fusion of the first and second polypeptide partners without the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers are characterized by a high content of serine, threonine, and proline, which can represent over 40% of the amino acids within the mucin domain.
Career Highlights
Leslie A McSweeney is currently employed at Alkermes, Inc., where she continues to innovate in the field of biotechnology. Her work has garnered attention for its potential applications in therapeutic development.
Collaborations
Throughout her career, Leslie has collaborated with notable colleagues, including Juan C Alvarez and Demetri Theodore Moustakas. These collaborations have contributed to her innovative research and development efforts.
Conclusion
Leslie A McSweeney
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