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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10183979 B1

PDFFull Text
Date of Patent:
Jan. 22, 2019

Filed:

Feb. 16, 2016

Fusion polypeptides comprising mucin-domain polypeptide linkers

Applicant:

Alkermes, Inc., Waltham, MA (US);

Inventors:

Juan Alvarez, Chelmsford, MA (US);

Leslie A. McSweeney, Milford, MA (US);

Assignee:

Alkermes, Inc., Waltham, MA (US);

Attorneys:

Elmore Patent Law Group, P.C.

Darlene Vanstone

Carolyn Elmore

Primary Examiner:

Michael Pak

Int. Cl.
CPC ...
C07K 14/435 (2006.01); C07K 14/55 (2006.01); C07K 14/47 (2006.01); C07K 14/545 (2006.01); C07K 14/54 (2006.01); C07K 14/715 (2006.01); C07K 14/50 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/575 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); C07K 14/4713 (2013.01); C07K 14/4727 (2013.01); C07K 14/50 (2013.01); C07K 14/54 (2013.01); C07K 14/545 (2013.01); C07K 14/5412 (2013.01); C07K 14/5443 (2013.01); C07K 14/57563 (2013.01); C07K 14/70503 (2013.01); C07K 14/71 (2013.01); C07K 14/7155 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C07K 2319/74 (2013.01); C07K 2319/91 (2013.01);
Abstract

The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.

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