Leland J Gershell

Title: Leland J Gershell: Innovator in Pharmaceutical Chemistry

Introduction

Leland J Gershell is a notable inventor based in New York, NY, with a significant contribution to the field of pharmaceutical chemistry. He holds a total of four patents, showcasing his innovative approach to drug development and synthesis.

Latest Patents

One of Gershell's latest patents involves Isometheptene isomer, which relates to a purified Isometheptene compound. This invention includes a hydrochloride or a pharmaceutically acceptable addition salt. The synthesis, purification, and characterization of an Isometheptene isomer mucate crystal 2 are particularly noteworthy. The (R)-enantiomer of Isometheptene is characterized as a selective centrally acting ligand for Imidazoline subtype 1 (I1) receptor sites. This compound is believed to provide an effective antihypertensive composition for treating migraine and other neurovascular or neurogenic pain. The (R)-Isometheptene enantiomer is expected to have lower side effects compared to its racemate form, making it a promising candidate for episodic tension-type headaches (ETTH). Additionally, methods of synthesis and treatment are described, along with data from X-ray crystallography.

Another significant patent by Gershell involves cytodifferentiating agents and histone deacetylase inhibitors. This invention provides a compound that selectively induces growth arrest, terminal differentiation, and apoptosis of neoplastic cells, thereby inhibiting their proliferation. Furthermore, it includes a method for treating patients with tumors characterized by the proliferation of neoplastic cells, along with a pharmaceutical composition that contains a therapeutically acceptable amount of the compound.

Career Highlights

Throughout his career, Leland J Gershell has worked with prestigious institutions such as the Sloan-Kettering Institute for Cancer Research and Columbia University. His work has significantly impacted the field of cancer research and pharmaceutical development.

Collaborations

Gershell has collaborated with notable individuals in his field, including Ronald C Breslow and Sandro Belvedere. These collaborations have likely contributed to the advancement of his research and innovations.

Conclusion

Leland J Gershell is a distinguished inventor whose work in pharmaceutical chemistry has led to significant advancements in drug development. His innovative patents reflect his commitment to improving treatment options for various medical conditions.