The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2008
Filed:
Jun. 22, 2006
Ronald Breslow, Englewood, NJ (US);
Sandro Belvedere, New York, NY (US);
Leland Gershell, New York, NY (US);
Thomas A. Miller, New York, NY (US);
Paul A. Marks, Washington, CT (US);
Victoria M. Richon, New York, NY (US);
Richard A. Rifkind, New York, NY (US);
Ronald Breslow, Englewood, NJ (US);
Sandro Belvedere, New York, NY (US);
Leland Gershell, New York, NY (US);
Thomas A. Miller, New York, NY (US);
Paul A. Marks, Washington, CT (US);
Victoria M. Richon, New York, NY (US);
Richard A. Rifkind, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
The present invention provides the compound having the formula: wherein each of Rand Ris, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.