Leah A Appel

Title: Innovations in Drug Delivery: The Contributions of Leah A. Appel

Introduction

Leah A. Appel is an accomplished inventor based in Bend, Oregon. She has made significant contributions to the field of pharmaceuticals, particularly in drug delivery systems. Her innovative work has led to the development of a unique dosage form that enhances the controlled release of medication.

Latest Patents

Leah A. Appel holds a patent for a hydrogel-driven layered drug dosage form. This controlled release dosage form for sertraline features a core that comprises a sertraline-containing composition and a water-swellable composition. The water-swellable composition is strategically placed in a separate region within the core. The coating around the core is designed to be water-permeable and water-insoluble, featuring at least one delivery port. This innovative dosage form is engineered to release sertraline at an average rate of 6 to 10 wt % per hour from the second to the twentieth hour after introduction to a use environment. It also ensures that less than about 25 wt % is released during the first two hours, while at least 70 wt % is delivered by the twelfth hour.

Career Highlights

Leah A. Appel is currently employed at Pfizer Corporation, a leading global pharmaceutical company. Her work focuses on developing advanced drug delivery systems that improve patient outcomes. With her expertise, she has contributed to the advancement of pharmaceutical technologies.

Collaborations

Leah has collaborated with notable colleagues, including William John Curatolo and Kenneth C. Waterman. These partnerships have fostered innovation and have been instrumental in the development of her patented technologies.

Conclusion

Leah A. Appel's contributions to drug delivery systems exemplify the impact of innovative thinking in the pharmaceutical industry. Her patented hydrogel-driven dosage form represents a significant advancement in controlled release technology.