The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Dec. 20, 2000
William J. Curatolo, Niantic, CT (US);
Kenneth C. Waterman, East Lyme, CT (US);
Avinash G. Thombre, East Lyme, CT (US);
Michael B. Fergione, Stonington, CT (US);
Michael C. Roy, Gales Ferry, CT (US);
Leah A. Appel, Bend, OR (US);
Danni Supplee, Bend, OR (US);
Dwayne T. Friesen, Bend, OR (US);
Mark B. Chidlaw, Bend, OR (US);
Ronald A. Beyerinck, Bend, OR (US);
William J. Curatolo, Niantic, CT (US);
Kenneth C. Waterman, East Lyme, CT (US);
Avinash G. Thombre, East Lyme, CT (US);
Michael B. Fergione, Stonington, CT (US);
Michael C. Roy, Gales Ferry, CT (US);
Leah A. Appel, Bend, OR (US);
Danni Supplee, Bend, OR (US);
Dwayne T. Friesen, Bend, OR (US);
Mark B. Chidlaw, Bend, OR (US);
Ronald A. Beyerinck, Bend, OR (US);
Pfizer Inc, New York, NY (US);
Abstract
A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt % per hour from the second to the twenth hour after introduction to a use environment and less than about 25 wt % for the first two hours and at least 70 wt % by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet. In another embodiment, the dosage form releases less than about 25 wt % of sertraline to the use environment by the second hour after introduction of the dosage form to the use environment, and delivers at least 25 wt % from the eighth to the twenty-fourth hour.