Company Filing History:
5 out of 9 
1 out of 310 
1 out of 1,991 
Years Active: 2006-2025
Title: Innovations by Lawrence Mielnicki in Cholesteryl Ester Nanoparticle Technology
Introduction
Lawrence Mielnicki, based in Buffalo, NY, is a notable inventor with a significant impact in the field of biomedical innovations. He holds six patents that showcase his pioneering work, particularly in the development of novel drug delivery systems utilizing cholestosome vesicles.
Latest Patents
Among his latest patents, Mielnicki has developed methods of treatment using cholestosome vesicles for incorporating molecules into chylomicrons. The invention revolves around a cargo-loaded cholesteryl ester nanoparticle, referred to as a 'cholestosome'. This structure contains a hollow compartment made up of at least one non-ionic cholesteryl ester and encapsulated active molecules which are unable to effectively pass through enterocyte membranes without being loaded into the cholestosome. This system, characterized by a neutral surface, replicates the absorption pathways of lipid nutrients, allowing it to reach the Golgi apparatus within cells. Ultimately, these innovative cholestosomes are designed to safely deposit active therapeutic or diagnostic molecules within the cells of a patient.
Career Highlights
Throughout his career, Mielnicki has made significant contributions to the field while working with firms such as Therasyn Sensors, Inc. and Health Research, Inc. His work at these organizations has focused on translating groundbreaking research into practical applications that can enhance patient care and treatment efficacy.
Collaborations
Mielnicki has collaborated with distinguished professionals in his field, including Jerome J Schentag and Mary P McCourt. These partnerships have further propelled his innovations, enhancing the quality and impact of their combined research efforts.
Conclusion
Lawrence Mielnicki's inventive work in cholesteryl ester nanoparticle technology represents a significant advancement in drug delivery methodologies. His ongoing research and patent developments continue to pave the way for innovative treatments that enhance the health and well-being of patients.