Company Filing History:
Years Active: 2023-2024
Title: Innovations by Laura Perin
Introduction
Laura Perin is an accomplished inventor based in Burbank, CA (US). She has made significant contributions to the field of biomedical engineering, particularly in the development of innovative technologies for renal disease modeling.
Latest Patents
Laura Perin holds 2 patents, with her latest invention being a glomerulus on a chip designed to recapitulate the human glomerular filtration barrier. This innovative device utilizes human podocytes and glomerular endothelial cells seeded into microfluidic chips. In long-term cultures, the cells maintain their morphology, form capillary-like structures, and express slit diaphragm proteins. This system effectively mimics the functions and structure of the glomerulus, including its permselectivity. When exposed to sera from patients with anti-podocyte autoantibodies, the chips demonstrate albuminuria proportional to the patients' proteinuria, a phenomenon not observed with sera from healthy controls or individuals with primary podocyte defects. The applicability of this technology extends to renal disease modeling and drug testing.
Career Highlights
Throughout her career, Laura has worked with notable institutions, including Children's Hospital Los Angeles and Bussolati, Benedetta. Her work has significantly advanced the understanding of kidney function and disease.
Collaborations
Laura has collaborated with esteemed colleagues such as Stefano Da Sacco and Roger De Filippo, contributing to the advancement of her research and innovations.
Conclusion
Laura Perin's innovative work in developing a glomerulus on a chip exemplifies her commitment to advancing biomedical engineering and improving renal disease modeling. Her contributions continue to impact the field significantly.