Laura Alexandra Johnson

Title: Innovations and Contributions of Laura Alexandra Johnson

Introduction

Laura Alexandra Johnson is a prominent inventor based in Ardmore, PA (US). She has made significant contributions to the field of cancer treatment through her innovative research and development of novel therapeutic methods. With a total of 4 patents, her work has the potential to impact the lives of many patients suffering from cancer.

Latest Patents

One of her latest patents is titled "Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor." This invention provides compositions and methods for treating diseases associated with the expression of EGFRvIII. It also relates to a chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. Additionally, the invention includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain. Another significant patent is "Cell secreted minibodies and uses thereof." This invention relates to compositions and methods for using a minibody, which includes a secretion signal, a variable heavy chain fragment, a variable light chain fragment, a constant chain fragment, and a hinge domain between the variable light chain fragment and the constant chain fragment. One aspect includes a nucleic acid encoding a minibody, while other aspects include compositions comprising a minibody and a modified T cell comprising a nucleic acid encoding a minibody. The invention also encompasses methods and pharmaceutical compositions comprising the modified T cells for adoptive therapy and treating conditions such as cancer.

Career Highlights

Laura has worked with notable organizations, including Novartis AG and the University of Pennsylvania. Her experience in these esteemed institutions has allowed her to further her research and contribute to advancements in medical science.

Collaborations

Throughout her career, Laura has collaborated with esteemed colleagues, including Jennifer Brogdon and Carl H. June. These partnerships have fostered a collaborative environment that enhances innovation and research in her field.

Conclusion

Laura Alexandra Johnson's contributions to cancer treatment through her innovative patents and collaborations highlight her dedication to improving patient outcomes. Her work continues to inspire future advancements in medical research and therapy.