The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Apr. 12, 2019
Novartis Ag, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Jennifer Brogdon, Sudbury, MA (US);
Laura Alexandra Johnson, Media, PA (US);
Carl H. June, Merion Station, PA (US);
Andreas Loew, Boston, MA (US);
Marcela Maus, Lexington, MA (US);
John Scholler, Narberth, PA (US);
Hideho Okada, Pittsburgh, PA (US);
Novartis AG, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.