Location History:
- Gainesville, FL (US) (2004 - 2009)
- Mansfield, TX (US) (2009 - 2014)
Company Filing History:
8 out of 2,928 
7 out of 188 
1 out of 5,448 
Years Active: 2004-2025
Title: The Innovative Contributions of Laszlo Prokai
Introduction
Laszlo Prokai is a renowned inventor based in Gainesville, FL, recognized for his significant contributions to the field of nanotechnology and its applications in medical imaging and therapeutic delivery systems. With a remarkable portfolio of 10 patents, Prokai’s work has paved the way for innovative approaches to the delivery of radio-imaging agents and therapeutic nucleic acids.
Latest Patents
Among his latest patents, Prokai's work on "Reconstituted HDL nanoparticles for delivery of radioactive agents and uses thereof" stands out. This invention addresses the limited attention towards lipoprotein-based delivery systems in radio-imaging applications. Prokai introduced a novel hydrophobic radio-imaging tracer that can be encapsulated into reconstituted HDL nanoparticles. These nanoparticles target the Scavenger Receptor type B1 (SR-B1), which is overexpressed on cancer cells due to their heightened cholesterol demands, allowing for in-vivo tumor targeting. The patent encompasses synthesis methods, characterization of the HDL/tracer complex, and both in-vitro and in-vivo studies.
Another important patent is centered on "HDL particles for delivery of nucleic acids." This innovation involves high-density lipoprotein-nucleic acid particles, which contain an apolipoprotein, therapeutic nucleic acids, and a polypeptide with a positively charged region that associates with the nucleic acids. These particles, along with pharmaceutical compositions that include the specified components, open new avenues for therapeutic applications.
Career Highlights
Laszlo Prokai has made significant strides through his association with esteemed institutions such as the University of Florida Research Foundation and the University of North Texas. His experience in these organizations has been instrumental in fostering innovation in the fields of medical imaging and drug delivery.
Collaborations
Throughout his research endeavors, Prokai has collaborated with notable colleagues, including Katalin Prokai and James W. Simpkins. Their collaborative efforts have contributed greatly to the advancements in the understanding and application of nanotechnology in healthcare.
Conclusion
Laszlo Prokai's innovative work and prolific patent portfolio reflect his dedication to advancing medical technology. By creating novel delivery systems for imaging agents and therapeutic nucleic acids, he continues to inspire a new generation of researchers and inventors in the field. His contributions not only enhance the efficiency of cancer treatment but also foster a greater understanding of the biological applications of nanotechnology.