Larry B Tsai

Title: Larry B Tsai: Innovator in Polypeptide Secretion and Recombinant Proteins

Introduction

Larry B Tsai is a prominent inventor based in Agoura, CA (US). He has made significant contributions to the field of biotechnology, particularly in the area of polypeptide secretion and recombinant proteins. With a total of 4 patents to his name, Tsai's work has had a substantial impact on the industry.

Latest Patents

One of Tsai's latest patents focuses on the enhanced secretion of polypeptides. This patent provides a signal peptide sequence and nucleic acids encoding this sequence, which are useful for improving the secretion efficiency of nerve growth factor (NGF) polypeptides. Additionally, it outlines a method for preparing Met-less NGF polypeptides. Another notable patent addresses the control of norleucine incorporation into recombinant proteins. This innovation suggests that norleucine incorporation can be inhibited by culturing cells expressing gene products in media with high levels of leucine and/or methionine, or by expressing the gene products in a leu mutant. Conversely, norleucine incorporation may be promoted by culturing cells in media containing norleucine or deficient in leucine and/or methionine. This method allows for the production of norleucine analogs of various proteins, including IL-2 and GCSF.

Career Highlights

Throughout his career, Larry B Tsai has worked with notable companies, including Amgen Inc. His expertise in biotechnology has allowed him to contribute to various innovative projects and advancements in the field.

Collaborations

Tsai has collaborated with esteemed colleagues such as Shi-Yuan Meng and Charles Frederick Morris. These partnerships have further enriched his work and expanded the scope of his inventions.

Conclusion

Larry B Tsai is a distinguished inventor whose work in polypeptide secretion and recombinant proteins has made a lasting impact on biotechnology. His innovative patents and collaborations highlight his commitment to advancing the field.