Kristina Pfendler-Bonham

Title: Kristina Pfendler-Bonham: Innovator in Stem Cell Research

Introduction

Kristina Pfendler-Bonham is a prominent inventor based in South San Francisco, CA (US). She has made significant contributions to the field of stem cell research, particularly in the differentiation of pluripotent stem cells into hepatocytes. With a total of 3 patents, her work has implications for drug screening and clinical therapies.

Latest Patents

One of her latest patents focuses on protocols for making hepatocytes from embryonic stem cells. This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ layer cells, then into hepatocyte precursors, and finally into mature cells. The cells obtained exhibit morphological features and phenotypic markers characteristic of human adult hepatocytes. They also show evidence of cytochrome P450 enzyme activity, validating their utility for commercial applications such as drug screening and the manufacture of medicaments and medical devices for clinical therapy.

Career Highlights

Throughout her career, Kristina has worked with notable companies in the biotechnology sector, including Geron Corporation and Asterias Biotherapeutics, Inc. Her expertise in stem cell technology has positioned her as a key figure in advancing medical research and applications.

Collaborations

Some of her coworkers include Ramkumar Mandalam and Saadia Faouzi, who have collaborated with her on various projects in the field of stem cell research.

Conclusion

Kristina Pfendler-Bonham's innovative work in stem cell differentiation has the potential to revolutionize therapeutic applications and drug development. Her contributions continue to impact the scientific community and pave the way for future advancements in regenerative medicine.