Company Filing History:
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1 out of 6 Years Active: 2002-2013
Title: Klaus-Peter Radtke: Innovator in Antibody Purification
Introduction
Klaus-Peter Radtke is a notable inventor based in Apex, North Carolina, with a significant contribution to the field of antibody purification. He holds six patents, showcasing his innovative approach to improving processes in biochemistry and pharmaceuticals. His work has had a profound impact on the efficiency and effectiveness of antibody purification methods.
Latest Patents
One of Klaus-Peter Radtke's latest patents is a chromatographic method for high yield purification and viral inactivation of antibodies. This improved process involves suspending antibodies at a pH of 3.8 to 4.5, followed by the addition of caprylic acid and a pH shift to between 5.0 and 5.2. A precipitate of contaminating proteins, lipids, and caprylate forms and is subsequently removed, allowing the majority of the antibodies to remain in solution. Sodium caprylate is added to achieve a final concentration of at least 15 mM, and the solution is incubated for one hour at 25°C to effect viral inactivation. The resulting clear solution is diluted with purified water to reduce ionic strength. Anion exchange chromatography using two different resins is then employed to obtain an exceptionally pure IgG with a subclass distribution similar to the starting distribution. This method maximizes yield and produces gamma globulin with greater than 99% purity, while the resin columns used retain IgM and IgA, which can be eluted in high yield and purity.
Career Highlights
Throughout his career, Klaus-Peter Radtke has worked with prominent companies such as Bayer Healthcare LLC and Bayer Corporation. His experience in these organizations has allowed him to refine his skills and contribute to significant advancements in the field of biopharmaceuticals.
Collaborations
Klaus-Peter Radtke has collaborated with notable colleagues, including Patricia Alred and Scott A Cook. These partnerships have fostered an environment of innovation and have led to the development of groundbreaking techniques in antibody purification.
Conclusion
Klaus-Peter Radtke's contributions to the field of antibody purification through his innovative patents and collaborations highlight his importance as an inventor. His work continues to influence the biopharmaceutical industry, ensuring the production of high-quality antibodies for various applications.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.