Company Filing History:
Years Active: 2006
Title: Innovations by Klaus Fuetterer in Anti-Bacterial Compounds
Introduction
Klaus Fuetterer is an accomplished inventor based in St. Louis, MO (US). He has made significant contributions to the field of microbiology, particularly in the development of anti-bacterial compounds. His work focuses on addressing the challenges posed by Gram-negative pathogens that utilize adhesive pili structures to colonize host tissues and cause disease.
Latest Patents
Klaus Fuetterer holds a patent for "Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof." This innovative patent describes novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. The invention also details the complex formed from the binding of these mimic compounds to the hydrophobic groove of a pilus subunit. By competitively interacting with the binding site of pili subunits, these compounds negatively affect the chaperone/usher pathway, which is a crucial mechanism for the assembly of adhesive pili structures in Gram-negative bacteria. This invention has the potential to prevent or inhibit pilus assembly, offering a new approach to combat bacterial infections.
Career Highlights
Klaus Fuetterer is affiliated with Washington University, where he continues to advance research in the field of microbiology. His work has garnered attention for its innovative approach to tackling bacterial adhesion and infection mechanisms. With a focus on practical applications, his research aims to contribute to the development of effective treatments against Gram-negative bacterial infections.
Collaborations
Klaus has collaborated with notable researchers in his field, including Scott J Hultgren and Frederic G Sauer. These collaborations have further enriched his research and contributed to the advancement of knowledge in the area of anti-bacterial compounds.
Conclusion
Klaus Fuetterer's innovative work in developing anti-bacterial compounds represents a significant advancement in the fight against bacterial infections. His contributions to microbiology and patenting of novel compounds highlight the importance of research in addressing public health challenges.