The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2006
Filed:
Aug. 11, 2000
Scott J. Hultgren, St. Louis, MO (US);
Frederic G. Sauer, St. Louis, MO (US);
Gabriel Waksman, St. Louis, MO (US);
Klaus Fuetterer, St. Louis, MO (US);
Devapriya Choudhury, Uppsala, SE;
Stefan D. Knight, Uppsala, SE;
Michelle Barnhart, St. Louis, MO (US);
Scott J. Hultgren, St. Louis, MO (US);
Frederic G. Sauer, St. Louis, MO (US);
Gabriel Waksman, St. Louis, MO (US);
Klaus Fuetterer, St. Louis, MO (US);
Devapriya Choudhury, Uppsala, SE;
Stefan D. Knight, Uppsala, SE;
Michelle Barnhart, St. Louis, MO (US);
Washington University, St. Louis, MO (US);
Abstract
Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. The present invention also relates to the complex formed from the binding of such mimic compounds to the hydrophobic groove of a pilus subunit. Competitively interacting with the binding site of pili subunits will negatively affect the chaperone/usher pathway, which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures, and thus prevent or inhibit pilus assembly.