Frederic G Sauer

Title: Frederic G Sauer: Innovator in Anti-Bacterial Compounds

Introduction

Frederic G Sauer is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of microbiology, particularly in the development of anti-bacterial compounds. With a total of 2 patents, his work focuses on innovative solutions to combat Gram-negative pathogens.

Latest Patents

Sauer's latest patents include "Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity" and "Therapeutic compounds structurally-linked to bacterial polypeptides." The first patent addresses the assembly of adhesive pili structures on the surfaces of Gram-negative pathogens, which allow them to colonize host tissues and cause disease. This invention introduces novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. By competitively interacting with the binding site of pili subunits, these compounds can negatively affect the chaperone/usher pathway, thereby preventing or inhibiting pilus assembly. The second patent discloses a protein construct that comprises a pilus protein portion and an additional effector portion, which serves to stabilize the pilus protein and confer therapeutic activities, such as vaccine activity or anti-microbial effects.

Career Highlights

Frederic G Sauer has worked with prestigious institutions, including Washington University and MedImmune Limited. His research has significantly advanced the understanding of bacterial adhesion mechanisms and the development of therapeutic strategies against bacterial infections.

Collaborations

Sauer has collaborated with notable colleagues, including Scott J Hultgren and Solomon Langermann. These partnerships have contributed to the success of his research and the impact of his inventions in the field.

Conclusion

Frederic G Sauer's innovative work in anti-bacterial compounds showcases his dedication to addressing critical health challenges posed by Gram-negative pathogens. His patents reflect a commitment to advancing medical science and improving therapeutic options.