Keriann M Backus

Title: Keriann M Backus: Innovator in Chemoproteomics

Introduction

Keriann M Backus is a prominent inventor based in La Jolla, California. She has made significant contributions to the field of chemoproteomics, focusing on the interactions between small molecules and proteins. With a total of 2 patents, her work has advanced the understanding of protein modification and its implications in biological systems.

Latest Patents

Keriann's latest patents include groundbreaking research on cysteine-reactive ligands. One patent describes a competitive activity-based profiling method that quantifies the reactivity of electrophilic compounds against over 1000 cysteines in the human proteome. This method identifies proteins that are hotspots for modification by lipid-derived electrophiles, such as the oxidative stress product 4-hydroxnonenal (HNE). Another patent focuses on methods and compositions for identifying cysteine-containing proteins as binding targets for small molecule fragments. This work is crucial for mapping biologically active cysteine sites on proteins and screening for interactions.

Career Highlights

Keriann M Backus is affiliated with The Scripps Research Institute, where she conducts her research. Her innovative approaches have garnered attention in the scientific community, contributing to advancements in understanding protein interactions and modifications.

Collaborations

Keriann has collaborated with notable scientists, including Benjamin F Cravatt and Chu Wang. These collaborations have further enriched her research and expanded the impact of her work in the field.

Conclusion

Keriann M Backus is a trailblazer in the realm of chemoproteomics, with her patents paving the way for new discoveries in protein interactions. Her contributions are vital for advancing scientific knowledge and potential therapeutic applications.