Company Filing History:
Years Active: 2025
Title: Innovations by Kensaku Hosoguchi
Introduction
Kensaku Hosoguchi is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of antibody variants. His work focuses on enhancing the efficacy and safety of therapeutic antibodies.
Latest Patents
Kensaku Hosoguchi holds a patent for an "Antibody variant and isoform with lowered biological activity." This patent describes antibody variants and isoforms that exhibit reduced FVIII mimetic activity compared to Emicizumab. The invention includes Q-CDR-Clipped Variants, which have specific amino acid residues in the variable region cleaved out and missing. Additionally, it features Protected Disulfide Isoforms, which possess inter-heavy chain disulfide bonds that are less susceptible to reduction under mild reducing conditions. This innovative approach aims to improve therapeutic outcomes in patients.
Career Highlights
Kensaku Hosoguchi is associated with Chugai Seiyaku Kabushiki Kaisha, a leading pharmaceutical company in Japan. His work at Chugai has been instrumental in advancing the company's research and development efforts in antibody therapies. With a focus on innovative solutions, he continues to contribute to the field of biotechnology.
Collaborations
Kensaku has collaborated with notable colleagues, including Maki Kuwayama and Chifumi Seida. Their combined expertise has fostered a collaborative environment that enhances the research and development of new therapeutic options.
Conclusion
Kensaku Hosoguchi's contributions to the field of biotechnology, particularly through his patent on antibody variants, highlight his innovative spirit and dedication to improving patient care. His work continues to influence the development of advanced therapeutic solutions.