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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12421322 B1

PDFFull Text
Date of Patent:
Sep. 23, 2025

Filed:

Oct. 31, 2018

Antibody variant and isoform with lowered biological activity

Applicant:

Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;

Inventors:

Kensaku Hosoguchi, Tokyo, JP;

Maki Kuwayama, Tokyo, JP;

Chifumi Seida, Tokyo, JP;

Yosuke Watanabe, Tokyo, JP;

Nobuyuki Tanaka, Tokyo, JP;

Satoshi Saitoh, Tokyo, JP;

Masakazu Fukuda, Tokyo, JP;

Assignee:

Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Zachariah Lucas

Assistant Examiner:

Lia E Taylor

Int. Cl.
CPC ...
C07K 16/46 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); G01N 33/6854 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/51 (2013.01); C07K 2317/565 (2013.01); C07K 2317/71 (2013.01); C07K 2317/94 (2013.01);
Abstract

As antibody variants and isoforms having reduced FVIII mimetic activity than Emicizumab, the antibody variants having some specific amino acid residues in the variable region cleaved out and missing (Q-CDR-Clipped Variants) and the antibody isoforms having inter-heavy chain disulfide bonds less susceptible to reduction under mild reducing conditions (Protected Disulfide Isoforms) are provided.

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Quick Actions:

Hosoguchi, Kensaku. (2025). Antibody variant and isoform with lowered biological activity (U.S. Patent No. 12421322). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12421322

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