Location History:
- Concord, MA (US) (1999 - 2005)
- Carlisle, MA (US) (1998 - 2018)
Company Filing History:
5 out of 1,307 
3 out of 818 
2 out of 4 Years Active: 1998-2018
Title: Kenneth Walsh: Innovator in Hematology and Cardiology
Introduction
Kenneth Walsh is a prominent inventor based in Carlisle, MA (US), known for his significant contributions to the fields of hematology and cardiology. With a total of 13 patents to his name, Walsh has made remarkable strides in understanding and treating various medical conditions.
Latest Patents
One of his latest patents is titled "Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development." This patent demonstrates how a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in TET2 leads to pro-inflammatory IL-1β signaling at multiple levels. The findings include increased IL-1β transcription, enhanced NLRP3 inflammasome-mediated IL-1β secretion, and amplified IL-1-Receptor 1-mediated IL-1β signaling. The patent provides compositions, methods, and assays for modulating TET2 mutation-mediated IL-1β proinflammatory activity, particularly when caused by somatic mutations in TET2.
Another significant patent is the "Method of treating ischemic injury with follistatin-like 1 polypeptide." This patent describes methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and its derivatives can be utilized to treat or prevent metabolic diseases or disorders and to mitigate cardiac damage caused by interrupted blood supply to cardiac muscle.
Career Highlights
Throughout his career, Kenneth Walsh has worked with esteemed institutions such as Case Western Reserve University and Boston University. His research has focused on innovative approaches to address critical health issues, particularly in the realms of hematology and cardiology.
Collaborations
Walsh has collaborated with notable colleagues, including David H. Gorski and Yuichi Oshima, contributing to a rich exchange of ideas and advancements in their respective fields.
Conclusion
Kenneth Walsh's innovative work and numerous patents reflect his dedication to advancing medical science, particularly in understanding and treating complex diseases. His contributions continue to impact the fields of hematology and cardiology significantly.