Company Filing History:
Years Active: 1977-1982
Title: Innovations of Kenneth P. Shephard
Introduction
Kenneth P. Shephard is a notable inventor based in Portage, MI (US). He has made significant contributions to the field of pharmacology through his innovative processes in steroid production. With a total of 4 patents to his name, Shephard's work has paved the way for advancements in the synthesis of pharmacologically active compounds.
Latest Patents
One of his latest patents is titled "Process for producing 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroids." This patent discloses two processes, one-pot and two-pot, for transforming a 6.beta.-fluoro-.DELTA..sup.1,4 -3-keto steroid to a 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroid. These innovative processes allow for the introduction of a fluorine atom at the 6.alpha. position of a .DELTA..sup.1,4 -3-keto steroid, which was previously challenging. The resulting 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroids serve as intermediates in the production of pharmacologically active steroids. Another significant patent involves an epoxide process, where 11.beta.,21-Dihydroxypregna-1,4,17(20)-triene-3-one 21-acetate is epoxidized, followed by ring opening and hydrolysis to yield 11.beta.,20,21-trihydroxypregna-1,4,16-triene-3-one 21-acetate, an important intermediate in the synthesis of betamethasone, achieved in improved yields.
Career Highlights
Kenneth P. Shephard has had a distinguished career at The Upjohn Company, where he has focused on innovative pharmaceutical research. His work has contributed to the development of new steroid compounds that have significant therapeutic applications.
Collaborations
Throughout his career, Shephard has collaborated with various professionals in the field, including his coworker Verlan H. Van Rheenen. These collaborations have enhanced the research and development processes within the company.
Conclusion
Kenneth P. Shephard's contributions to the field of pharmacology through his innovative