Location History:
- Nevada, IA (US) (1999 - 2000)
- Neveda, IA (US) (2003 - 2014)
- Colo, IA (US) (2011 - 2020)
Company Filing History:
9 out of 1,195 
5 out of 260 
4 out of 270 
Years Active: 1999-2020
Title: Innovator Spotlight: Kelly M Lager - Advancing Veterinary Vaccines
Introduction: Kelly M Lager is a prominent inventor based in Colo, Iowa, known for his groundbreaking contributions to the field of veterinary vaccines. With an impressive portfolio of 14 patents, Lager has focused his efforts on developing innovative strategies to combat viral diseases in animals, particularly swine.
Latest Patents: Among Lager's most notable recent patents are the development of viable viruses with foreign tags for Multiple DIVA (Differentiating Infected from Vaccinated Animals) vaccines aimed at effectively addressing porcine reproductive and respiratory syndrome virus (PRRSV). These vaccines can be classified as negative or positive DIVAs and involve modifications to the nsp2 region of modified live virus vaccines. By implementing deletions or insertions (such as epitope tags like V5, S-Tag, or FLAG tag), the produced vaccines demonstrate stability through multiple passes, enhancing their efficacy for animal vaccination.
Additionally, Lager's innovations extend to genetically engineered swine influenza viruses. These attenuated viruses have been modified to impair their ability to antagonize the cellular interferon (IFN) response, making them suitable for vaccine and pharmaceutical formulations. The modifications to the swine NS1 gene result in decreased replication and virulence, thereby increasing the attenuation and making them highly effective for use in live virus vaccines.
Career Highlights: Throughout his career, Kelly M Lager has collaborated with recognized institutions such as the United States of America, as represented by the Secretary of Agriculture, and St. Jude Children's Research Hospital. His work has substantially contributed to advancing the field of veterinary medicine and improving vaccine options for livestock.
Collaborations: Lager has worked alongside esteemed professionals in his field, including William L Mengeling and Ann C Vorwald. Their combined expertise has amplified the impact of Lager's innovations, further advancing vaccine technology and public health in veterinary medicine.
Conclusion: Kelly M Lager's inventive contributions and unwavering commitment to improving animal health through innovative vaccine solutions underscore the importance of research and development in combating infectious diseases. His continued efforts in the field of veterinary vaccines not only enhance the well-being of livestock but also contribute to agricultural sustainability and food safety.