The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Dec. 12, 2016
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
The United States of America, As Represented BY the Secretary of Agriculture, Washington, DC (US);
Peter Palese, New York, NY (US);
Adolfo Garcia-Sastre, New York, NY (US);
Richard J. Webby, Memphis, TN (US);
Juergen A. Richt, Ames, IA (US);
Robert G. Webster, Memphis, TN (US);
Kelly M. Lager, Colo, IA (US);
Icahn School of Medicine at Mount Sinai, New York, NY (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
The United States of America, As Represented by the Secretary of Agriculture, Washington, DC (US);
Abstract
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.