Keith Williams

Title: Keith Williams and Automated Organoid Imaging

Introduction

Keith Williams is an inventor associated with Cell Microsystems, Inc., in Durham, North Carolina. His patent work addresses automated imaging, identification, and isolation of organoids for research applications.

Latest Patents

Williams is associated with 1 patent, titled “Automated System for Imaging, Identification, and Isolation of Organoids.” The invention combines a microwell array designed for organoid culture with an instrument system that images, identifies, and isolates individual organoids. Releasable cellrafts in the microwells allow selected organoids to be transferred intact to a collection plate.

The system supports tracking, imaging, and phenotypic analysis in brightfield and fluorescence as organoids grow. Its demonstrated applications include imaging individual mouse hepatic and pancreatic organoids, generating clonal organoids, subcloning parent organoids, and extracting RNA from single organoids for downstream gene-expression or transcriptomic analysis.

Career Highlights

Williams’s listed patent connects his work at Cell Microsystems with tools for organoid culture and analysis. The system is designed to automate the selection and transfer of organoids while preserving them for subsequent research.

Collaborations

The provided information lists Rachel Allysa Stern and Jessica Kessler Hartman as Williams’s coworkers. Their specific roles in the patent or related work are not specified.

Conclusion

Keith Williams’s patent describes an automated approach to imaging and isolating organoids, supporting their analysis and use in downstream research.