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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12770416 B1

PDFFull Text
Date of Patent:
Oct. 20, 2026

Filed:

Mar. 28, 2024

Automated system for imaging, identification, and isolation of organoids

Applicant:

Cell Microsystems, Inc., Durham, NC (US);

Inventors:

Rachel Allysa Stern, Rougemont, NC (US);

Jessica Kessler Hartman, Cary, NC (US);

Steven Charles Gebhart, Durham, NC (US);

Caleb Macrae Fleming, Cary, NC (US);

Brandon Thompson, Durham, NC (US);

Keith Williams, Durham, NC (US);

Robert W. Mcclellan, Apex, NC (US);

Assignee:

Cell Microsystems, Inc., Durham, NC (US);

Attorney:

KDW FIRM PLLC

Primary Examiner:

Ming Shui

Int. Cl.
CPC ...
G06V 20/69 (2022.01); C12M 1/32 (2006.01); C12M 1/34 (2006.01); C12M 1/36 (2006.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01); G06T 7/162 (2017.01);
U.S. Cl.
CPC ...
G06V 20/698 (2022.01); C12M 23/12 (2013.01); C12M 41/12 (2013.01); C12M 41/36 (2013.01); C12M 41/48 (2013.01); G06T 7/0012 (2013.01); G06T 7/11 (2017.01); G06T 7/162 (2017.01); G06V 20/693 (2022.01); G06V 20/695 (2022.01); G06T 2200/24 (2013.01); G06T 2207/10024 (2013.01); G06T 2207/10064 (2013.01); G06T 2207/20072 (2013.01); G06T 2207/30024 (2013.01);
Abstract

A microwell array specifically designed for culturing organoids is provided along with a system to enable automated imaging, identification, and isolation of individual organoids. The microwells of the microarray include a releasable cellraft that enables the automated release and transfer of selected organoids present on the cellrafts to a separate collection plate. Organoids grown on the microarray can be reliably tracked, imaged, and phenotypically analyzed by the instrument system in brightfield and fluorescence as they grow over time, then released and transferred fully intact for use in downstream applications. The use of the system is demonstrated using mouse hepatic and pancreatic organoids for single-organoid imaging, clonal organoid generation, parent organoid subcloning, and single-organoid RNA extraction for downstream gene expression or transcriptomic analysis.

Find Patent Forward Citations

Quick Actions:

Stern, Rachel. (2026). Automated system for imaging, identification, and isolation of organoids (U.S. Patent No. 12770416). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12770416

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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