Caleb Macrae Fleming

Title: Caleb Macrae Fleming and Organoid Research

Introduction

Caleb Macrae Fleming is an inventor based in Cary, North Carolina, and works at Cell Microsystems, Inc. His patent work concerns tools for imaging, identifying, and isolating organoids for research.

Latest Patents

Fleming is associated with one patent, titled “Automated System for Imaging, Identification, and Isolation of Organoids.” The invention combines a microwell array designed for organoid culture with an automated system for imaging, identifying, and isolating individual organoids. Each microwell includes a releasable cellraft, allowing selected organoids to be released and transferred intact to a collection plate.

The system can track, image, and analyze organoids over time using brightfield and fluorescence imaging. Its demonstrated applications include imaging individual mouse hepatic and pancreatic organoids, generating clonal organoids, subcloning parent organoids, and extracting RNA from single organoids for gene-expression or transcriptomic analysis. Fleming’s listed patent portfolio comprises 1 patent.

Career Highlights

Fleming’s documented invention addresses the handling and analysis of organoids, which are used in biological research. By combining culture, imaging, analysis, and intact transfer in an automated workflow, the system is designed to support downstream experiments.

Collaborations

Fleming’s listed coworkers include Rachel Allysa Stern and Steven C. Gebhart. The patent is associated with Cell Microsystems, Inc.

Conclusion

Caleb Macrae Fleming’s patent work focuses on an automated platform for studying and isolating organoids, connecting imaging and analysis with their transfer for further research.