Keith W Yaeger

Title: Innovator Keith W. Yaeger: Advancements in Recombinant Proteins

Introduction: Keith W. Yaeger, an accomplished inventor based in Madison, Wisconsin, has made significant contributions to the field of biotechnology. With a focus on enhancing protein solubility and functionality, Yaeger holds a patent that underscores his innovative approach to recombinant protein production.

Latest Patents: Yaeger's notable achievement is the patent for Recombinant Rabbit Tissue Factor. This invention involves cloning and producing a complex protein in a bacterial host. As recombinant rabbit tissue factor is relatively insoluble due to its disulfide bonds, special modifications are required for its expression and purification at commercial levels. By utilizing thioredoxin as a fusion protein, Yaeger successfully increased the solubility of the tissue factor. The method also incorporates a thioredoxin reductase deficient host, which is crucial for maintaining the correct tertiary structure essential for the protein's biological activity.

Career Highlights: Keith W. Yaeger is currently associated with Pel-Freez, a company focused on producing high-quality biological products. His expertise in recombinant proteins has positioned him as a key player in this innovative sector. His work contributes to advancements in medical and research applications, which are vital for scientific communities.

Collaborations: Throughout his career, Yaeger has collaborated with notable colleagues such as Robert E. Novy and Michael J. Domanico. These partnerships have fostered a dynamic environment of innovation and research, amplifying the impact of their collective efforts in the field of biotechnology.

Conclusion: Keith W. Yaeger exemplifies the spirit of innovation in the biotech industry. Through his groundbreaking work with recombinant rabbit tissue factor, he has made significant strides in improving protein production processes. His collaborations and contributions underscore the importance of teamwork in advancing scientific knowledge and commercial applications.