The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 1999
Filed:
Jul. 16, 1996
Applicant:
Inventors:
Robert E Novy, Jr, Verona, WI (US);
Michael J Domanico, Madison, WI (US);
Keith W Yaeger, Madison, WI (US);
Warren Kroeker, Madison, WI (US);
Assignee:
Pel-Freez, Rogers, AR (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 696 ; 435 697 ; 43525233 ; 530381 ; 530415 ; 536 231 ; 536 235 ; 536 237 ; 536 241 ;
Abstract
Recombinant rabbit tissue factor is cloned and produced in a bacterial host. This protein, which is relatively insoluble and has several disulfide bonds, requires special modifications in order to express and be purified at commercial levels. By expressing the tissue factor as a fusion protein with a bacterial enzyme, thioredoxin, solubility is increased. Use of a thioredoxin reductase deficient host aids in proper tertiary structure for biological activity.