Kazumi Shimono

Title: Kazumi Shimono: Innovator in Membrane Protein Synthesis

Introduction

Kazumi Shimono is a notable inventor based in Kanagawa, Japan. He has made significant contributions to the field of protein synthesis, particularly in the production of membrane proteins. His innovative methods have the potential to advance research in various biological applications.

Latest Patents

Kazumi Shimono holds a patent for a method of using cell-free protein synthesis to produce a membrane protein. This method allows for the production of a membrane protein that is folded to its native or active structure within a lipid disc or liposome. The process involves preparing a reaction solution that includes a polynucleotide encoding the membrane protein, a steroidal detergent, and a phospholipid. The steroidal detergent is used at a concentration higher than its critical micelle concentration, followed by a decrease in its concentration during the synthesis process. This innovative approach enables the simultaneous synthesis of the membrane protein and the formation of a lipid disk or liposome, into which the synthesized protein is integrated.

Career Highlights

Kazumi Shimono is associated with Riken Corporation, a leading research institution in Japan. His work at Riken has focused on advancing techniques in protein synthesis, contributing to the understanding of membrane proteins and their functions.

Collaborations

Kazumi Shimono has collaborated with notable colleagues, including Shigeyuki Yokoyama and Mikako Shirouzu. Their combined expertise has fostered advancements in the field of protein research.

Conclusion

Kazumi Shimono's innovative methods in membrane protein synthesis represent a significant advancement in biotechnology. His contributions continue to influence research and development in the field, showcasing the importance of innovation in scientific progress.